Citrix Technology Professional (CTP) Alexander Ervik Johnsen has written a very useful piece on how best to configure Citrix XenApp and Citrix Edgesight when using Anti-Virus solutions.
AV is recognized as a major drain of shared resource in a Citrix XenApp environment, Ervik provides some recommendations to reduce the aggressiveness of the AV scans.
“The following are suggestions to help ease the negative affect that standard Anti-virus settings can cause on Citrix XenApp servers. As these servers are not used in the normal sense of the word Server, the scan and realtime aggressiveness needs to be adjusted for the Antivirus Software or performance will be affected.”